Powerful Ingredients for Strength and Vitality

Our muscle health supplement is a powerhouse of ingredients specifically formulated for seniors to support strength, mobility, and overall vitality. As a foundation this potent formula features a blend of Essential Amino Acids (EAAs) with an elevated level of Branched-Chain Amino Acids (BCAAs), supplying the body with highly absorbable protein. Each ingredient plays a crucial role in muscle health, and they work together to boost protein synthesis, aid recovery, and provide sustained energy—empowering seniors to stay active and resilient.

Essential Amino Acid Blend

EEA Blend 7g: L-Leucine 2.5g, L-Isoleucine 1.25g, L-Valine 1.25g, L-Lysine 1g, L-Threonine 600mg, L-Phenylalanine 250mg, L-Histidine 50mg, L-Methionine 50mg, L-Tryptophan 50mg

EAAs consist of nine amino acids that our body cannot produce on its own. All nine EAAs are the basic building blocks of all our body protein, critical for muscle growth, repair, and overall recovery, as well as supporting other vital functions such as our immune system. Their rapid absorption ensures efficient delivery to muscles, optimizing protein synthesis and supporting lean muscle maintenance.

The ratio of amino acids in a standard EAA formula mirrors the composition found in human muscle tissue. The primeLIfespan blend contains elevated BCAA levels (Branch Chain Amino Acid), particularly L-Leucine, enhancing the anabolic potential by directly activating the mTOR pathway, a key regulator of muscle protein synthesis. This specialized ratio is specifically designed to maximize muscle support and promote strength and recovery, beyond what standard EAA formulations can achieve. In a nutshell Leucine acts as the "trigger" for protein synthesis, while the other EAAs provide the necessary building blocks for new muscle proteins. Leucine also supports energy production, blood sugar regulation, and the body’s response to stress, contributing to enhanced physical performance and recovery. Leucine’s multifunctional role in the body makes it an invaluable nutrient, particularly for older adults.

Because they are already in their free form, EAAs mostly bypass complex digestion and are quickly digested in the small intestines, rapidly entering the bloodstream to trigger muscle-building pathways.  Unlike whole protein sources such as whey, EAAs are absorbed efficiently, making them particularly beneficial for those looking to optimize muscle synthesis, recovery, and overall health without the digestive workload of larger protein molecules.  For seniors, who often face slower digestive and metabolic processes, this enhanced absorption is crucial. It translates to better muscle retention, quicker recovery, and improved muscle function, making EAAs an ideal choice for maintaining strength and independence with age.

Protein Synthesis Boosters

Our anabolic support ingredients featuring HMB, Velositol®, Creatine, L-Citrulline, Beta-Alanine, and Ellagic Acid—are designed to accelerate muscle growth, enhance recovery, and optimize strength, giving your body the tools it needs to thrive:

HMB (β-Hydroxy β-methylbutyrate) 581.4mg

HMB (Beta-Hydroxy Beta-Methylbutyrate) is a metabolite of the amino acid Leucine that plays a key role in muscle metabolism. HMB enhances muscle building and retention by promoting protein synthesis while reducing muscle protein degradation, providing a dual-action approach that is especially beneficial for preventing age-related muscle loss (sarcopenia). HMB activates the mTOR pathway, a key regulator of cell growth and muscle protein synthesis, which is essential for muscle repair and growth. At the same time, HMB prevents muscle breakdown by blocking a key process that causes muscle protein loss, especially during inactivity or aging. This balanced promotion of muscle anabolism and inhibition of catabolism allows HMB to effectively preserve and build lean muscle mass.

For seniors, HMB supplementation has been shown to improve muscle strength, enhance muscle function, and support physical resilience, helping maintain an active and independent lifestyle. HMB also supports immune health and has positive effects on bone and cardiovascular health, contributing to overall vitality.

 

Velositol® (Amylopectin Chromium Complex) 1g

Velositol® is an advanced, patented ingredient designed to enhance the effects of protein on muscle synthesis, making it a powerful addition to any muscle-building or maintenance regimen. Composed of a unique blend of amylopectin, a complex carbohydrate, and chromium, Velositol® works synergistically to amplify muscle protein synthesis beyond what protein alone can achieve.

Velositol® specifically enhances muscle building and retention by boosting the body's response to protein intake, making each gram of protein more effective. By doubling the muscle protein synthesis rate, Velositol® helps increase muscle growth, improve strength, and enhance overall body composition. This process is crucial for muscle growth, repair, and maintenance, especially in older adults who may experience slower muscle-building responses due to aging. Velositol also helps regulate insulin levels, which plays a key role in driving nutrients into muscles and preventing muscle protein breakdown.

For seniors, Velositol® is an invaluable tool in combating muscle loss and promoting a more active lifestyle as they age.

Creatine Monohydrate 1.5g

Creatine is a compound synthesized from three amino acids: arginine, glycine, and methionine. Creatine is found in muscle cells that boost energy production during high-intensity activities and allows muscles to generate more ATP, the primary energy source for muscle contractions.  Creatine is highly effective for muscle building and retention by increasing muscle cell hydration and enhancing energy availability. It promotes muscle growth by improving protein synthesis and promotes muscle repair.

For seniors, creatine helps counteract sarcopenia by boosting muscle strength, increasing lean mass, and supporting better overall physical function. Beyond improving strength and performance, creatine supports brain health, reduces fatigue, and enhances muscle recovery, making it a valuable supplement for all ages, especially seniors experiencing age-related declines in muscle mass and energy.

L-Citrulline 1g

L-Citrulline is a naturally occurring amino acid that plays an important role in nitric oxide (NO) production, which helps improve blood flow and cardiovascular health. L-Citrulline is efficiently converted into L-Arginine in the kidneys, leading to increased nitric oxide levels without the quick breakdown that direct L-arginine supplementation can encounter. By enhancing vasodilation, or the widening of blood vessels, L-Citrulline supports better oxygen and nutrient delivery to tissues, which can boost physical performance, reduce fatigue, and support cardiovascular function. This improved circulation also helps lower blood pressure and supports overall cardiovascular health, making L-Citrulline a versatile supplement for individuals looking to enhance both physical performance and heart health.

By increasing nitric oxide production, L-Citrulline promotes efficient delivery of amino acids and oxygen to muscles, supporting both muscle protein synthesis and quicker recovery from exertion. Additionally, L-Citrulline has been shown to reduce the accumulation of ammonia, a metabolic byproduct that contributes to muscle fatigue, allowing for sustained performance during exercise.

Beta-Alanine 500mg

Beta-alanine is a non-essential amino acid that plays a crucial role in enhancing physical performance by increasing muscle carnosine levels. Carnosine acts as a buffer against acid buildup in muscles during intense exercise allowing for longer and more effective exercise. Beta-alanine’s ability to boost muscle carnosine levels makes it highly effective for improving muscle endurance and reducing fatigue. By delaying the onset of muscle acidosis, beta-alanine allows for longer, more intense muscle contractions, which enhances strength and performance over time.

For seniors, this means not just better exercise quality but also improved muscle retention and function, as prolonged activity stimulates muscle protein synthesis. Beta-alanine helps combat the natural decline in muscle endurance associated with aging. Additionally, beta-alanine has antioxidant properties that help protect muscle cells from damage, supporting overall muscle health and recovery.

  • Essential Amino Acids

    "Essential amino acid supplementation resulted in a 198% increase in muscle protein synthesis in elderly subjects compared to a 141% increase in the young, demonstrating that EAAs effectively stimulate muscle protein synthesis regardless of age"

    Paddon-Jones, D., Sheffield-Moore, M., Zhang, X. J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004). Amino acid ingestion improves muscle protein synthesis in the young and elderly. American Journal of Physiology. Endocrinology and Metabolism, 286(3), E321–E328

  • HMB (Beta-Hydroxy Beta-Methylbutyrate)

    "Supplementation with HMB attenuated the decline in muscle mass during 10 days of bed rest, preserving muscle mass by 6% more than the placebo group, suggesting its efficacy in preventing muscle atrophy during periods of inactivity"

    Deutz, N. E., Pereira, S. L., Hays, N. P., Oliver, J. S., Edens, N. K., Evans, C. M., & Wolfe, R. R. (2013). Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clinical Nutrition, 32(5), 704–712.

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  • Strength Renew 50+ includes targeted anti-aging ingredients including TMG, Taurine, Shilajit, and Magnesium Malate to support cellular health, energy production, and muscle preservation, helping you stay strong, active, and resilient as you age.

  • Betaine Anhydrous or Trimethylglycine (TMG) 1.5g

  • Trimethylglycine (TMG), also known as Betaine, is a naturally occurring compound found in foods like beets, spinach, and whole grains. It is an amino acid derivative and plays a vital role in cellular hydration, liver function, and methylation, a process crucial for DNA repair and cardiovascular health. By supporting these key biological functions, TMG helps improve energy levels, reduce inflammation, and enhance overall physical and mental performance.


    TMG supports muscle health by enhancing cellular hydration and protecting muscles from stress during physical activity. It boosts muscle power and endurance, allowing for more effective workouts and improved recovery. TMG also aids in reducing muscle protein breakdown and promoting lean muscle retention, which is particularly valuable for seniors as they age.

  • Shilajit Extract (std to 50% Fulvic Acid) 250mg

  • Shilajit is a mineral-rich resin found in the Himalayas, prized for its energizing and rejuvenating effects. Packed with fulvic acid and over 80 essential minerals, Shilajit enhances energy production at the cellular level, reduces inflammation, and supports nutrient absorption. Known as a powerful adaptogen, it helps the body adapt to stress, boosts immunity, and promotes longevity, making it especially beneficial for maintaining vitality with age. Shilajit supports muscle health through multiple mechanisms that enhance energy production and reduce oxidative stress within muscle cells, which collectively help prevent fatigue and improve endurance.


    Rich in fulvic acid, Shilajit boosts mitochondrial function by facilitating ATP production, the primary energy source for muscle contractions. This increase in cellular energy not only aids performance during physical activity but also supports endurance by enhancing muscle resilience under stress.


    Additionally, Shilajit’s contributes to the removal of cellular toxins and improves nutrient absorption, thus optimizing the cellular environment for faster muscle repair, especially critical for seniors.

  • Pomegranate Extract (Punica granatum) (std. to 40% Ellagic Acid) 200mg

  • Ellagic acid is a potent antioxidant found in fruits like pomegranates, strawberries, and raspberries. Ellagic acid is particularly beneficial for muscle health due to its ability to mitigate oxidative stress and inflammation - key contributors to muscle atrophy - by downregulating pro-inflammatory markers like NF-κB and cytokines. It also protects muscle tissue by reducing oxidative damage in mitochondria, a vital factor in preserving muscle function and strength.

    Studies indicate that ellagic acid also activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which is linked to improved cellular resilience and may indirectly support muscle protein synthesis. These combined effects mean ellagic acid supports muscle health, growth, and recovery, by creating a favorable environment for muscle maintenance.

    Ellagic acid is also known for its immune health support and detoxifying effects, as it aids the liver in processing toxins. These combined benefits make ellagic acid an excellent supplement for promoting healthier aging and resilience against environmental stressors.

  • Magnesium Malate 60mg

  • Magnesium malate is a highly bioavailable form of magnesium combined with malic acid, a compound naturally found in fruits and essential for energy production in the body. Magnesium is a vital mineral involved in over 300 biochemical reactions in our body, including those related to nerve function, bone health, cardiovascular support, and muscle relaxation.

    As we age, magnesium levels can decline, leading to symptoms such as fatigue, muscle cramps, and impaired muscle function. Magnesium malate is particularly effective because it not only replenishes magnesium stores but also provides malic acid, which supports the Krebs cycle, the body's process for generating energy. This dual-action makes magnesium malate a popular choice for maintaining overall health, enhancing energy, and reducing muscle discomfort.

    Magnesium malate plays an important role in senior muscle health not only by ensuring that muscles receive an adequate supply of magnesium but also by helping to regulate calcium in muscle cells, preventing excessive calcium buildup that can lead to cramping and muscle stiffness.

  • Velositol (R)

    "When added to 6g of protein, Velositol doubled the muscle protein synthesis response compared to what was seen with protein alone, demonstrating significant enhancement of protein's anabolic effect"

    Ziegenfuss, T.N., Lopez, H.L., Kedia, A., Habowski, S.M., Sandrock, J.E., Raub, B., Kerksick, C.M., & Ferrando, A.A. (2017). Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein. Journal of the International Society of Sports Nutrition, 14, 6.

  • Creatine Monohydrate

    "Creatine supplementation in combination with resistance training increased lean tissue mass by 6.3% and bench press and squat strength by 24-32% in older men, compared to 3.1% increase in lean tissue and 16% increase in strength with resistance training alone"

    Brose, A., Parise, G., & Tarnopolsky, M. A. (2003). Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 58(1), 11–19.

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Clinical Study References

Essential Amino Acids

Role of Essential Amino Acids in Protein Synthesis and Muscle Growth
Open Access Journals

Effects of Resistance Exercise and Essential Amino Acid Intake on Muscle Quality
MDPI

Essential Amino Acids and Protein Synthesis
PubMed Central

Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals
Frontiers

Free amino acids are more readily available than intact protein but do not induce a differential effect on muscle protein synthesis rates
America Society of Nutrition

Daniel Tome, Efficiency of Free Amino Acids in Supporting Muscle Protein Synthesis, The Journal of Nutrition, Volume 152, Issue 1, January 2022, Pages 3–4
The Journal of Nutrition

Ingestion of Free Amino Acids Compared with an Equivalent Amount of Intact Protein Results in More Rapid Amino Acid Absorption and Greater Postprandial Plasma Amino Acid Availability Without Affecting Muscle Protein Synthesis Rates in Young Adults in a Double-Blind Randomized Trial, The Journal of Nutrition, Volume 152, Issue 1, January 2022, Pages 59–67
The Journal of Nutrition

International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance
Journal of the International Society of Sports Nutrition

L-Leucine

The Effectiveness of Leucine on Muscle Protein Synthesis in Older People
Cambridge University Press

Research Progress in the Role and Mechanism of Leucine in Muscle Protein Synthesis
Frontiers

Double-blind, Placebo-controlled Pilot Trial of L-Leucine-enriched Amino Acid Supplementation in Elderly Patients
National Library of Medicine

HMB (β-Hydroxy β-methylbutyrate)

Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
National Library of Medicine

Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions"
National Library of Medicine

"Effect of β-hydroxy-β-methylbutyrate (HMB) on the Muscle Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis"
National Library of Medicine

"Effects of leucine and its metabolite β‐hydroxy‐β‐methylbutyrate on human skeletal muscle protein metabolism"
The Physiological Society

Velositol™ (Amylopectin Chromium Complex)

Effects of a novel chromium complex combined with whey protein on muscle protein synthesis and recovery following resistance exercise
NutraIngredients

Amylopectin/chromium complex increases skeletal muscle protein synthesis in vivo
Nutritional Outlook

The addition of amylopectin/chromium complex to whey protein augments muscle strength adaptations following 8-weeks of resistance training
Nutrition21

The addition of anamylopectin /chromium complex to branched-chain amino acids enhances muscle protein synthesis in rat skeletal muscle
National Library of Medicine

Creatine Monohydrate

Highlights:

Creatine supplementation during resistance training increases the number of repetitions performed by 45.4% from baseline (compared to 22.9% for placebo) and the weight lifted by 24.7% from baseline (compared to 13.4% for placebo)

For short, high-intensity exercise bouts (≤30 seconds), creatine supplementation results in a 7.5% increase in performance from baseline, compared to a 4.3% increase for placebo

Studies:

Creatine supplementation with specific view to exercise/sports performance: an update
PubMed Central

Nutritional Regulation of Muscle Protein Synthesis with Resistance Exercise
Nutrition & Metabolism

Effect of Creatine Supplementation During Resistance Training on Lean Tissue Mass and Strength in Older Adults: A Meta-Analysis
DovePress

Creatine Supplementation for Muscle Growth: A Scoping Review of Randomized Clinical Trials from 2012 to 2021
PubMed Central

L-Citrulline

Highlights:

L-citrulline supplementation combined with exercise increased muscle protein synthesis by up to 48% in animal models, compared to 27% for exercise alone and 33% for citrulline alone.

In human trials, short-term L-citrulline malate supplementation increased peak power output by 9%, total work by 7%, and exercise tolerance by 12% during high-intensity cycling.

Studies:

Synergistic Effects of Citrulline Supplementation and Exercise on Muscle Protein Synthesis
Portland Press

Chronic L-Citrulline Supplementation Improves Skeletal Muscle Power and Metabolism
Portland Press

L-Citrulline Supplementation: Impact on Cardiometabolic Health
PubMed Central

Beta Alanine

Highlights

Beta-alanine supplementation (6.4 g/day) for 4–10 weeks increased muscle
carnosine concentrations by 30–35% and improved high-intensity cycling
capacity. Both type I and II muscle fibers showed similar increases in
carnosine.

A systematic review (2024) concluded that beta-alanine supplementation
(2.4–3.2 g/day for 10–12 weeks) may improve exercise capacity (as
measured by physical working capacity at fatigue threshold, PWCFT, and
time to exhaustion) in older adults.

In a randomized controlled study, 30 strength athletes supplementing
with 6.4 g/day of beta-alanine for 5 weeks showed significant increases
in average strength, maximum strength, and strength endurance compared
to placebo during a progressive strength training program

Studies

Effects of Beta-Alanine on Muscle Carnosine and Exercise Performance
PubMed Central

The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review and Meta-Analysis
frontiers

Role of β-Alanine Supplementation on Cognitive Function, Mood, and
Physical Function in Older Adults; Double-Blind Randomized Controlled

PubMed Central

Beta-Alanine for Improving Exercise Capacity, Muscle Strength,
and Functional Performance of Older Adults: A Systematic Review

Journal of Aging and Physical Activity

Betaine Anhydrous or Trimethylglycine (TMG)

Highlights

A randomized, double-blind study found that six weeks of betaine
supplementation (2.5 g/day) in resistance-trained men led to significant
increases in lean mass and arm size, as well as improved muscle
endurance and work capacity

Betaine acts as a methyl donor, supporting DNA methylation and reducing toxic homocysteine levels, which are associated with cardiovascular and neurological risks in aging populations. It also helps maintain methionine homeostasis and protects against metabolic-associated liver disease, oxidative stress, and inflammation

Studies

Effects of Betaine on Body Composition, Performance, and Homocysteine Thiolactone
PubMed Central

Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations
Science Direct

Beneficial Effects of Betaine: A Comprehensive Review
PubMed Central

Ellagic Acid from Pomegranate Extract

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health
PubMed

Shilajit Extract

Highlights

A clinical study in overweight/class I obese adults found that 12 weeks
of oral Shilajit supplementation (250 mg twice daily) upregulated genes
involved in muscle repair, elasticity, and regeneration (e.g., collagen,
elastin, fibronectin) without adverse effects on blood glucose or lipid
profiles. This suggests Shilajit may promote skeletal muscle adaptation
and support muscle health, especially in populations at risk of muscle
decline

Another study showed that 8 weeks of Shilajit supplementation (500
mg/day) helped retain maximal muscular strength after fatigue and
promoted favorable adaptations in muscle and connective tissue,

Studies

The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation
PubMed Central

The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels
PubMed Central

Shilajit extract reduces oxidative stress, inflammation, and bone loss to
dose-dependently preserve bone mineral density in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial

ScienceDirect

Magnesium Malate

Magnesium and muscle performance in older persons: the InCHIANTI study
PubMed Central

The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review
PubMed Central

Magnesium in Aging, Health and Diseases
mdpi